![]() Most case reports have made no effort to explain the mechanism underlying this apparently-paradoxical side-effect of heavy and prolonged cannabis use. Remarkably consistent, and all of which strongly implicate cannabis. Studies to conclude that cannabis was the cause of the problem.Īlthough controversial and little-studied, thisĬondition now numbers over two dozen case reports, all of which are Period of heavy and protracted cannabis use, leading the authors of the case This condition sought medical treatment for acute vomiting and nausea after a The few patients reported to have been affected by It typically occurs in those that have used cannabis heavily for numerous years. Phenomenon appears to affect chronic users that have used cannabis heavily forĬannabinoid hyperemesis syndrome causes cyclic vomiting, and a compulsive need to bathe to try to relieve the sensations of nausea and needing to vomit. Thought to cause certain serious and debilitating conditions. ![]() ![]() Sometimes cause unpleasant digestive problems. Negative effects of cannabisĪt the opposite end of the spectrum, cannabis use can Hunger (particularly the hypothalamus) and ultimately causing hunger pangs even Gut-brain axis to the brain regions responsible for issuing sensations of In animal studies, synthetic THC activates the ghrelin receptors, sending signals along the Stimulates the vagus nerves of the GI tract and travel up to the brain along the gut-brainĪxis to reach the hypothalamus, where the hunger pangs A hormone called ghrelin is released, which Normally, hunger pangs are generated when the stomach They are also known to reduce intestinal motility (basically, to reduce the speed at which matter passes through the intestine) and fluid secretions caused by inflammation, which helps to soothe nausea and prevent vomiting and diarrhoea. In general, cannabinoids may decrease inflammation in inflammatory bowel disease. These diseases appear to be promoted by spinal, peripheral and gastrointestional mechanisms, and the research suggests that cannabinoids can block these mechanisms. The first three conditions are even speculated to be a result of clinical endocannabinoid deficiency (CECD), a condition in which the individual does not produce enough cannabinoids or cannabinoid receptors. Multiple studies have demonstrated that cannabis can be helpful in the management of, IBD, IBS, fibromyalgia, Crohn’s, and cancer-related anorexia and cachexia (appetite loss and muscle wasting). Positive effects of cannabis use on the GI tract In rare cases,Ĭannabis can cause an acute vomiting syndrome known as cannabinoid hyperemesis syndrome, as well as potentially causing acute pancreatitis. Range of unusual and unexpected symptoms. Introducing extra cannabinoids to the GI tract is disruptive and can cause a On the other hand, in some individuals, the effect of This can be highly beneficial for people suffering from certain illnesses that affect the appetite, from cancer to eating disorders themselves, as well as otherwise-healthy individuals whose appetite loss is due to stress or other factors. In people who lack appetite, cannabis can be all that is needed to induce ravenous hunger. The endocannabinoid system is complex and finely-tuned This is particularly true in individuals suffering from certain gastrointestinal disorders, including Crohn’s, inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS). Cannabinoid receptors are widely distributed throughout the digestive system, as well as in the brain regions considered to be crucial to the gut-brain axis.įor some people, introducing extra cannabinoids to the finely-tuned endocannabinoid system of the gastrointestinal (GI) tract (the scientific term for the digestive system) can have positive effects. The endocannabinoid system is fundamentally important to the regulation of digestive processes including appetite, salivation, hunger, and satiety.
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